BioIR™ is a family of dedicated solutions for the biopharmaceutical industry based on FT-IR instrumentation
and comprised of specialized software and databases.
The first such system, PROTA™, was introduced in 1998 and has since rapidly become the industry’s preferred choice. PROTA™ provides a fast, cost-effective and sensitive way to determine secondary structure
of a protein or to follow structural changes due to perturbations. This turnkey system is designed to be used by both spectroscopists and non-spectroscopists. It’s user-friendly, intuitive software guides users through data acquisition and analysis. PROTA™ includes all of the functions, in one integrated package, required to link IR spectral data and protein structure.

Applications
· Formulation studies (liquids and solids) - effects of excipients, pH and buffers
· Determination of secondary structures of de novo proteins
· Conformational stability and dynamics
· Structure in aggregates
· Mutation studies
· Structural characterization upon environmental effects
· Stability studies (thermal and chemical)
· Drug delivery
· Protein-protein, protein-DNA/RNA and protein-drug interactions
· Crystallization condition screening

FT-IR spectrometer system

· ABB MB3000 FT-IR spectrometer consisting of:
√  Arid-Zone sample compartment with countercurrent purge flow in telescopic purge tubes
√  Non-hygroscopic ZnSe beamsplitter
√  High-sensitivity DTGS detector
· Resolution: 1 cm-1 - 128 cm^-1
· Spectral range: 6,500 - 500 cm^-1

Additional Hardware
· Pre-loaded PC
· BioCell™ with CaF2 windows
· Purge Control Kit

Software
· Windows-based integrated software for data acquisition and data analysis
· Complete Grams A/I software
· Protein FT-IR databases
√  Transmission
√  ATR
√  Excipients